Originally Posted by The Unbelievable Me
So most probably all of this has been said before but here goes:
(the below is from the boss faq by Haunter120 on gamefaqs)
Seymour Flux, Mortiorchis
HP: 70000, 4000
So you must deal about 70,000 damage without dying from his arsenal of attacks including mainly, Lance of Atrophy (again this info is stolen, with some ideas of my own and some not), Full-Life, Annihilation and dispel.
We can deal with these attacks thusly:
Lance of Atrophy casts zombie on a character- no threat a holy water quickly fies this and his follow up cast of Full-Life which would kill you heals you... no danger here.
Dispel can be annoying as haste is very helpful but once again it can be easily stopped, this time by silence (probably Wakka would be best for this, though Rikku's tosses are good for status).
Total Annihilation is his most dangerous move dealing maybe 3500-5000 damage. However Shell brings this move down a huge degree, it should do no more than 2000 to a shelled character. This can be cast by a white mage, or if you have it Kimahri's mighty guard.
Banish kills an aeon instantly, so only rely on a single attack from them such as an overdrive.
Seymour also has flare, but I think silence avoids that and a few other moves I can't recall- but nothing dangerous.
Your Way of Killing him:
There are many different ideas and here they are:
-Tidus is very useful, he does reasonable damage and can haste (hastega) your party.
-He has a huge weakness to poison which is easily exploited by a variety of moves, specifically bio from Lulu and item usage from Rikku.
-The standard Aeon sac strategy is effective, bringing in a few aeons with prepared overdrives can easily hugely deplete his HP.
-Heavy damage is of course helpful so your strongest characters should be used. Yuna's excellent as a healer/summoner and I like Tidus for haste skills and Wakka because of silence buster, which will keap Seymour on a leash.
-Wakka can stop Seymour from using dispel. This may not sound good but it means he won't cancel your haste or your shell- this turns out to be very helpful for surviving Annihilation.
He's probably (read:undoubtedly) the toughest yet but his attacks can all be equalized and with skills such as bio, aeons and strong attacks he shouldn't be too hard to knock off. If I remember rightly Mortiorchis has lower defense, so attacking it with physical attacks from Tidus or Auron is probably helpful (not Wakka because silencing Seymour is so helpful).
Hope this helps!