Let's see, I read quite a few.
Awkward Zombie: Some fun Smash Bros. themed comics, not too frequently updated but hey, who cares. Good for a laugh.
Three Panel Soul: The new project of the Mac Hall guys. A bit odd at times, but can be entertaining.
CAD: This one gets a lot of flack, but while it's certainly not my favorite it's not BAD. It gives me some degree of entertainment four times a week, so it's doing it's job.
Darths and Droids: Inspired by DM of the Rings, which I picked up on as it neared completion. I loved DM of the Rings, and this series, while approaching it a bit differently as far as the characterization, is quite well done.
Dominic Deegan: I used to like this one a lot more, but the recent storylines have been fairly meh. Still, it updates every day, so it's nice to keep up on. Art's fairly basic, but he does his own art and writing, which is something I can respect.
GPF: I'm not quite sure what I can say about this one, it's really weird with a lot of complicated plotlines and generally sci-fi mixed with modern mixed with fantasy. I read it over the course of a few nights and just kept reading it since at the time it was also an every day of the week update. Much slower now, but I keep reading it.
Order of the Stick/Erfworld: Order of the Stick is hands-down my absolute favorite webcomic out there right now. Side-splitting geek humor, a really interesting plot, and a great sense of comedic timing all make this a fantastic comic. Erfworld moves a bit slower, but is generally pretty interesting, I like the world they constructed for it.
Goblins - Life Through Their Eyes: Got off to a slower start, but with the advent of more plot it's gotten pretty good. I seem to be a sucker for all the good D&D comics, so there ya go.
Aoi House: My sister linked me to this one, and while it's fairly meh and it's right-to-left pretension annoys the ever-loving crap out of me, it can be reasonably decent and the premise is entertaining.
Gunnerkrigg Court: My girlfriend just linked me to this a few days ago, I devoured the archives. It's a good series, I like the use of lore and the setting is intriguing.
Least I Could Do (not linking for some less-than-kosher content): Generally pretty amusing, and updates every day but Sunday which is another point in it's favor. I'm really liking the current arc.
Looking for Group: By the guy who does Least I Could Do, it's a fun fantasy comic that's a lot more serious than it's beginnings would have made one suspect.
Megatoyko: It's pretty, and I don't mind the pretty shoujou-tastic plot. If only it moved faster.
Misfile: Updates every weekday which is nice, and does a good job portraying the identity crisis of having a gender change like that.
Penny Arcade: I was never really big on this one (though I did read through all the archives) until more recently, reading them one at a time gives you a chance to really appreciate the quality of some of the strips. While it can be hit-or-miss with me, I also really appreciate what these guys are to the gaming industry, so it's one I make a point of keeping up with.
And PAX is awesome.
Questionable Content: Great character-driven webcomic with frequent updates and excellent art. There's just a dash of fantasy to allow for more outrageous arcs, but in general is a slice-of-life story that I rather enjoy. I do tend to get lost in the Indy Music Babble though.
The Adventures of Dr. McNinja: SO. AWESOME.
VGcats: No link due to 'Kishi's prejudice. They've been more miss than hit lately and the update schedule's really bad, but when they have a hit, it tends to be pretty funny.
xkcd: Sometimes he goes spinning off into emo, and sometimes he's got way more science than I can comprehend, but a lot of the time the comic is just genuinely funny.
