General consensus is that the virus is on its way toward mutating into a form that's readily spreadable from human-to-human. Statistically, we're overdue for another global pandemic; with modern travel and trade going as fast as they are, any illness will be able to spread very rapidly once its in circulation. This was demonstrated by SARS which, while not fatal in over 95% of cases, was a brand-new disease that spread from country to country with remarkable speed.
Quarantine, border control and - if necessary - medical isolation are the best ways to approach an avian flu epidemic. Most countries have laws in place that'll allow this, so hopefully outbreaks can be contained, once they begin. It's probably a matter of "when" rather than "if", so the best we can do is hope for adequate preparation and a sufficiently speedy response.