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If you make sure that Madison survives to the hospital scene near the end, she (but not you) is told the identity of the Origami Killer. Understandably, she is shocked and aghast at the name she hears being associated with such atrocities. Not understandably, she and said killer have never met in the game at this point, and in fact are completely unaware of each other’s existence. She’s reacting to nothing, which becomes even more face-palm-worthy when she scoots immediately round to his house.