My hero would be futurama. Great writing, imagination and characters. My sides might not be splitting after watching it but I find it to be the most re-watchable.

South Park is a close second. I thought the show went down hill a bit when they went to the fourth grade. They brought it back big time and Butters is just too funny.

Family Guy may make about 39.3 off topic references per show but that has gotten a bit stale. I really enjoyed the first few seasons they had before they were canceled. Then when they came back they used the EXACT same jokes(greased up def guy). They failed to realize it should have been a one time thing.

Simpsons have been on too long. I would say they hit their prime in season 8 and after that it started to go down hill in quality. Now we are in gutter trash territory and it just isn't funny anymore. I use to enjoy watching re-runs but now I don't even bother due to all of the bad new stuff that I could potentially be threatened with.