Smith vs. Sephiroth

[Big D]

Smith is a computer program, so Sephiroth could take him out with the latest version of AVG.

Edit: But in terms of an actual fight if they were both real people with their on-screen powers...

As an Agent, death isn't a big deal for Smith. Especially not in his 'viral' form, where he can amass an army of copies in a short time.

Both are superhumanly strong and resilient. Both can fly (neither could do so originally, but gained the ability as they gained more power). Smith can dodge bullets, but is vulnerable to melee weapons and attacks - which Sephiroth favours.

Could go either way, I guess. But it pays to remember that Smith's combat style in Revolutions is limited to kicking, punching, and flying around the place at a fair clip. Sephiroth, on the other hand, has the range advantage of a sword, and can demolish pieces of buildings, to use as weapons or obstacles, with ease.