Is it possible to fly in some way?

[Big D]

Using genetic engineering to artificially lighten human bones, so they resemble thsoe of birds, would only result in further problems. You'd then have to lighten and weaken a lot of muslces, to avoid snapping the flimsy new bones, except for all the new muscles you'd need to make the wings work. It'd also probably be necessary to adjust the size or density of a lot of internal organs, too. Then there's the cardiovascular and metabolic work that'd be needed - flying with wings is very energy-intensive, hence why birds seem to spend inordinate amounts of time eating. On top of that, you'd have problems of bone-marrow shortage resulting from giving yourself hollow bones. I don't know enough about birds to say how they work in this regard.
Basically, though, to make a human capable of flight would require a whole lot more than just giving them the genes for wings and light bones.

[Spammerman]

Let's see, you can get bite by a radioactive spider with wings. Works for spider man. Except the wings...

how bout a radioactive hummingbird. nobody would expect it.

[sockmonkey]

Even the largest pterosaurs wieghed less than an adult human and they were right at the physiological limit for flight.