Depends on who's available. If 13 running backs are picked and it's my turn, why the hell would I pick the 14th best player at a position over the dynamic duo of Manning/Harrison? Though I fully expect Manning to go at pick 7 or 8. Toss another WR in there and say 11 RBs were taken. I could take the 12th and 13th best player at one position, or get a RB and a top 3 player at another position. I'm not saying don't pick a RB in the first two rounds, you are a fool not to, but to completely lock down a position that early in the draft limits your options not only in the draft, but as the season progresses. Let's say you see a breakout performance by a RB in week 1, or you notice a key injury to a top RB on a run heavy team in week 7. You could pick up that player and use him as a backup/trade bait, but football trades are hard to lock down. Rather than focus on one position early on, I think you would be wiser to spread out your talent to allow for mid season adjustments.