depends on the venue. in highschool i would say go for easy marks, but i never had lofty aspirations for college/university, and even though i was going into what i wanted (english/philosophy) both were, to me, easy credits, since i enjoy writing essays, and english was always mandatory anyway.

in college/university...well it depends on how you want your career lifestyle to work. if you want to do something you enjoy, pick something you enjoy. if you want to do something you find easy, pick something easy. if you want to do something that makes you a lot of money, pick something that will net you a lucrative career.