Demon's Crest? That game was sweet. I never knew much of the series it's from, though, and I only know that the main character of Demon's Crest appears as a villain in other games some how, but that was so long ago I heard that, it's validity is questionable.
According to the interwabz, though, there was a Gargoyle's Quest 2 for the NES, but no Gargoyle's Quest 1. That was for the GB. So I don't think Demon's Crest is a direct sequel, but rather, a nice spin-off, if it is actually related to Gargoyle's Quest. Thus, since Gargoyle's Quest 2 has no direct sequels, it qualifies for this topic.
Yupz.
Edit: I take that back. Gargoyle's Quest, in itself, is a spin-off of Ghosts and Goblins, in which you play as the Red Demon Mini-Boss character. Demon's Crest, is, indeed, a direct sequel to Gargoyle's Quest.