I always play in my room, often with a plate of food or something next to me and a bottle of water, the toilet's across the hallway from my room so I pretty much don't have to leave my room for hours. (Time flies when I play a good game).

If I'm in a part that I can't save and I can't be bothered going to a place that I can save in/finding a save point, I just turn off the TV and leave the PS2 running while I go do something else.