Tossup between Kuja and Mateus.
With Kuja, you've just been handed your ass on a silver platter, your party is half dead and he just walks up, gives you this disdainful look, and turns away. His whole attitude in that scene conveys pure contempt. Then he goes and flies away on a freakin' dragon. That scene is made of win.
Mateus, when you first see him in Origins, is torching a city. (Then sending hellspawn and soldiers to pick off the survivors. Bastard.) He's perfectly calm, too, which just makes it just... unnerving. I mean, he's incinerating a city full of people, with no more thought than one would give to stepping on an insect. Kind of gives you an idea of his general opinion of humanity.
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