The most annoying thing for me is the lack of a real limit to carry weight. Sure I move slowly and cannot jump around, however I can still walk away from a mission with 400 - 500 weight of items when my capacity is more like 150. Other than that this game so far is pretty remarkable as being a good addition to the Fallout Franchise, I was a little surprised however to notice the following though:

(SPOILER)Even though Fallout has always been 18 rated and very open about sex, more particulary prostitution and lesbian sexuality when you rent a room from Moriarty at Megaton prior to getting the free house for the deactivating the nuke mission (I haven't tried to rig it for the other side of the mission, I'm deciding to play nice, also megaton is useful to me for trading ect) to sleep in and Nova follows you up there is no conversation or even sound effect/notification to let the player know whether or not their character did have sex. This seems a little too Oblivionesque to me with it's safe for younger players environment but Fallout normally would openly allow you to hire a prostitute and use her with some kind of confirmation ect. I just didn't expect there to be nothing mentioned other than a fully clothed Nova sleeping on the bed whilst you're in the room also if you speak to her she leaves.