I believe he was part of the team that developed the virus and then started to work on a cure once it broke out. The events leading up to the break out and everything I think would be interesting. You would have government cover ups. The virus getting out might have been from terrorists. The reactions to what they have created could be bad. Maybe a different branch of the military got a hold of it and figured they could use these things in combat situations. There is a lot of potential for a very interesting story and it would give Smith a chance to show off more of his great acting skills. His reactions and protection of his family and how he deals with the mounting stress. Heck, they could take it a step further and have his family dying come into play during the movie in an uncut sort of way and see how he deals with that in the immediate aftermath of that situation.
The movie has a ton of potential to be good and interesting.
EDIT: I decided to try and find out what I had initially said about the develop of the virus thingy and I couldn't find it at all. I remember reading that someplace when I was researching the story well before the movie actually came out. That part might have been in one of the other movie adaptions "The Omega Man" and the other one...Last Man Alive or something.
Still a lot of the other things I said can be used like the protection of his family, terrorism, the after math of his family dying all the way up to how he became barricaded in his house in New York where everything was going down.





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