I'll do more recent films

Marley & MeMarley the dog dies
Bride WarsBride #1 calls of her wedding to a douchebag, attends as maid of honor for Bride #2's wedding
Slumdog MillionaireJamal correctly answers the final million dollar question, wins the game, ends up with the girl
MilkHarvey Milk dies
BlindnessThe first man struck with the sudden blindness can suddenly see again
The Curious Case of Benjamin ButtonBenjamin ages backward until he's a baby. Closes his eyes and dies.
The ReaderAfter spending 20+ years in prison for a bogus charge, Kate Winslet's character commits suicide right before being released
DoubtPriest gets sent to a different church, Meryl Streep's character admits to lying about having "proof" when she accused the Priest
Revolutionary RoadMarriage crumbles. Infidelity. Suburban despair. Wife tries to perform abortion on herself, dies. Husband moves away from the suburbs with the kids.
Seven PoundsWill Smith gives away body parts to various people needing transplants to make up for killing 7 people in a car accident. Commits suicide by jelly fish in order to donate cornea and heart