Well eventually in any MMO I either end up turning it down or off. Vent is one obvious reason, but sometimes I just bore of it. Also, sometimes it can be horrible. ToAU music was largely what got me in the habit of muting my music. Not to mention by then I was doing a lot of sitting around LFG or something (leveling DRG) and so I would mute the in-game music and do something productive on my other monitor.