I don't know if it would be considered a pick up "line" but I was talking to this one guy about a marketing class, and I was just saying how I'm not very good at selling stuff or something along those lines. And he then said "You look like something that would be on/in the advertisement, you look so good. Make me wanna' buy that Gatorade." (as I was drinking Gatorade at that point in time).
I don't know what that was but I thought it was funny.