Yep, Ninokuni will be/is there for sure.

So far, all they've talked about is Layton 4, which will be a prequel. 1UP said on a different forum they'll have videos up by 'midnight PST'.

They're also teasing 'crazy announcements'. Someone said someone from Namco Bandai is there.

I also doubt this will be the place they'll spend a lot of time on White Knight Chronicles 2, because that falls into the same category as Dark Cloud and Dragon Quest. They *might* tease it.