Am I the only one who sees this as a good sign? The proposed new direction sounds an awful lot like Marvel's Ultimate Spider-Man retcon series which started about a decade ago. Granted, I've not followed it since it was first released, but what I did read what a good adaptation of the original story.
I think this provides a pretty solid opportunity to do some very good things with the series. There's a lot of potential, and I'm not willing to shoot it down quite yet. As far as I'm concerned, ditching MacGuire and Dunst is a good thing for the series as a whole. It might be a bit soon for a new film adaptation, but I think if it's different enough, it won't matter.