You know, they could sort of explain zack and emma's significance by making them adam and eve (the skeletons from the caves).

And something interesting: Desmond said at the end of Happily Ever after to Ben, "I have a son named Charlie." Soooooo either freudian slip on the producers or a mistake or whatev it would mean "Island" Desmond killed Flocke after falling into the well.
Also Desmond doesn't know that Locke is dead. So he trusts him of course, why wouldn't he?