Is it status ailments or damage that's causing the problem?

I had a Ribbon so I didn't have to worry about status ailments. If you don't have a Ribbon, my advice is to get one =) Rafflesia, Carrot and Wild Malboro will destroy you without one. Ose and their Hell Blasters will probabley cause you massive problems in the Great Crystal. Most late Marks have some kind of status touch too (Behemoth King has Disease touch, Gilgamesh has both Stop touch and Sap touch etc)