God of War. You start off having killed the Hydra and feeling pretty much like a bad ass so when Athena asks you to stop Ares you're thinking, "okay, a god might be a little tougher but how bad could it be?" Of course the first time you see him towering over Athens reigning death and destruction on it you can't help but wonder how in the hell you're supposed to stop him.

And then when you've retrieved Pandora's box and are starting to think that maybe you can do it (SPOILER)Ares kills you and you fall into Hades wondering how the hell you're supposed to pull it off now.

And of course there's the fact that as you learn Kratos back story you can't help but feel that things won't end well for him, especially if you're even passingly familiar with a few greek myths.

I could probably think of some others, but I just had that on the brain after beating God of War III this week.