I wondered at Lucrecia's mental health and eyesight when it was revealed she chose Hojo over Vincent. And there wasn't really an explanation for that choice until DoC came along so for those who had never played or watched a playthrough of DoC Lucrecia was probably viewed as an irrational character

Hoboy am I glad that none of Hojo's physical features were inherited by Sephiroth, including that screechy voice *tries imagining Sephiroth with Hojo's voice and brain implodes* Don't try this at home, kids.