I don't think hardcore nerds who nitpick everything are the core audience of the show. You can't ever please those types, and they don't buy commercial products anyway. I think it's more for casual nerds and people who are sympethetic to casual nerds. For example, my brothers are more hardcore nerd than I am and they don't watch it, but my parents are not nerdy at all and they love it, and they definitely don't care which chemistry formulas are on the board.

This show gets the nerdy thing done more accurately than most mainstream shows do, and that's pretty cool. But it's hard to be perfect, especially in this realm.