Starcraft II.

And some of the Hard Mode achievements for the storyline are crazy. On your third mission, which is a hold the line mission where you have nothing but Marines and Medics, you get tasked with destroying four Zerg Hatcheries. I finally did this. Then I reloaded an autosave, because the assault was so costly that I didn't have the forces left to hold out against the massive final push. Fortunately, it wasn't one of the achievements that requires you complete the mission to achieve.