Demetri Martin and Zach Galifianakis have good bits with instruments. I've seen other people try it and so far no one has pulled it off as well as these two.
I listen to Dane Cook's CD's a lot but he can get really annoying when he goes off on a ten minute side story and has to go back to the joke I already forgot about.
Daniel Tosh is good too. I've only seen a few of his specials but I've been watching a lot of Tosh.0 lately and it's pretty good.
I like Jim Gaffigan too. He uses his awkwardness well.
I can't stand Blue Collar Comedy. All my friends rave about thatand I'm like "Really? It's been forever since that
came out and you're still talking about it?" That ass who uses puppets is pretty annoying too.