The correct answer is System Shock 2, but most people won't go through the trouble to play it. It's old and you MUST pirate it (for various BS reasons). There are a lot of mods that update the graphics and make it look quite nice. It's still the pinnacle of scary games to me. It used to give my wife nightmares. I'd be a douche and wait till she was half asleep and whisper "your song is not ours" and other creepy phrases from the amazing ambient sounds that made you want to crap your pants constantly.
No game has made me feel as alone as that game did. Doom 3 and especially Dead Space, which are essentially the same type of setting, at least had some semblance of other human contact. SS2 did not. You were utterly alone on the Von Braun.
Enemies weren't always permanently dealt with... merely pacified. Weapons could break, and ammo was at a premium (especially with endless enemies). I remember specifically jumping onto a stack of crates in the cargo bay and hiding from something making unheavenly noises below. I knew I had to go out there and take care of it, but I had to take a break in the game to give my heart a break in real life because I was so unnerved.
Sound is one of the biggest things in the game. Lots of ambient stuff and stuff that gets you on a subconscious level or something. I swear there's subliminal terror programmed into the ambient noise.
A lot of people always say F.E.A.R. like it's something special. I got that game specifically to be scared because people talked about how scary it was. I made a point of only playing it at night with headphones on in the pitch black. I was extremely underwhelmed.







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