(SPOILER)
What do you think about House and Cuddy? Will they last?
Honestly, I hope they don't last more than a small story arc at the beginning. House in state of happiness isn't the House that I want to watch on television. I don't watch the show for the doctor drama, I watch it to see how big of a douchebag Hugh Laurie is to his co-workers, patients, and friends. It was a nice touch on the season 6 finale, but if it lasts too long into season 7, I'll be sorely disappointed.

How about Thirteen leaving for a while?
When they first introduced her, I didn't really care for Thirteen (Amber was better). As the last season progressed, I became more fond of her until the point where they threw her into a relationship with Foreman (which I felt was somewhat forced). I ignored her for the duration and when they finally broke up, I was more interested in her. I hope she does come back eventually with a different sort of twist in her character (though not too glaring, like.. not primarily into chicks anymore) but I don't expect her to return until the 4th or 5th episode. We'll see though.

All-in-all, I'm excited to watch the new season but if it becomes too formulaic (moreso formulaic?) then I won't be too disappointed, there are better shows on this September.