Assuming they are released in 2011...

Will DEFINITELY be playing
Final Fantasy XIV: Ishgard release
Uncharted 3
Mass Effect 3
Crysis 2
Elder Scrolls V: Skyrim
Resistance 3
Final Fantasy Versus XIII

Am very interested in
Deus Ex Human Revolution
Duke Nukem Forever
Portal 2
Journey
The Last Story
Dragon Age II
Arkham City
Final Fantasy Agito XIII

Have raised an eyebrow at
Gears of War 3
Killzone 3
Diablo III
L.A. Noire
Rage
Mortal Kombat