151: VI is the only game in the series that has a paintbrush as a weapon.

152: Gau is still the only character in the series who can't use a weapon.

153: Kefka has the highest on screen, permanent body count in the series. Debatably, he has the highest body count in the series

154. VI is the first game to actually name their resistance group.

155. Setzer's theme is the second most used leitmotif in the game. Appearing in his own theme of course, Epitaph, and twice in the ending theme (once during his curtain call, the second during the actual credits)

156. VI is the last game to have a "tutorial school" by which I mean a building with people who give you hints on how to do things. This should not be confused with Cloud giving tutorials in VII or the tediously long lectures by Quistis in VIII.

157. VI is the first game not to feature the Dancer NPC who does a silly dance for you when prompted.

158. VI is the first game to bring in the Weapon as a boss enemy. Though Omega from V is counted by some fans, he actually doesn't use the term Weapon in his name and the first true Omega Weapon is in VIII.

159. VI is the only game that has the Creature Suit type armor.

160. In some of Sabin's character artwork, he actually sports a swanky beard.