I meant to comment on this when I originally saw it but then I forgot. I have to agree with Dreddz that none of the enemies are all that interesting to fight and that the gameplay is pretty weak overall. In fact, the longer the game goes on the more combat becomes a huge pain in the ass. From what I recall it never really gets far past being a simple beat 'em up and the only change that occurs with the enemies over the course of the game isn't that fights really get any harder or require many changes in tactics, but rather that they just take longer to finish than they do earlier in the game.
Infamous was an ok game but not something I would have been happy to have paid for if I got it before it was a Greatest Hits title. Outside of combat and the story missions there isn't a whole lot to it as far as variety, and like I said, I wasn't very taken with the combat and the story wasn't as great as people make it out to be if you ask me. It's a game that I feel was dramatically undermined by the inclusion of the morality system, and it relies on a lot of superhero tropes that I'm overly familiar with at this point having read superhero comics for more than 20 years now.