The licensing will probably be stored in the registry and your preferences in /user/app data/etc/lol so if you were able to run the app, your windows would be different and it would run as a 30 day trial or something.

At least, that was basically how it worked when I tried to run PS from a cd oh 8 years ago.

Portable apps suffer from a number of difficulties, not least of which having to access the USB drive for every action, which means they are smurfing slow in most cases. This is true even with non-cpu intensive (lol) apps like firefox, much less dreamweaver.just pirate it a few times imo