The best you'll get out of animation is a dramedy (god I hate the word...) and even then, those shows don't tend to last very long. Morel Orel started off as a funny satire of Middle America, Christianity, and the shear delusion that was the 1950's "Nuclear Family" ideal, but its last season actually had some crazy episodes and it really turned into this giant story about trying to live up to an unrealistic ideal and family issues. The stories about Orel's parents are rather poignant and disturbing to say the least, but its all dark humor anyway.

Mission Hill was a great series too that got one lousy season but despite some of its humor, I actually liked how relate-able it was to the slacker generation, and the idea of growing up.