Originally Posted by
demondude
A lot of Americans can't find Britain on a map - in terms of marketing they'll have a much higher chance of generating sales with a game set in the country of the largest customer base. Also if they were to properly satirise a country other than the US then the humour would not spread as well, whereas generally American culture is understood well enough in other parts of the world that buy into their media. For GTA, America is by far the best option if they actually want to make a titload of money.