Considering how good ZOE 2nd Runner was I'd love if Kojima did ZOE3! I will agree the MGS universe has little story to tell, Ocelot is dead, Liquid & Solidus dead, Snake with very little time left, FOXDIE dies along with Snake & the Patriots are gone. But then again Raiden, Otacon, Meryl, Johnny & Sunny are alive if they really wanted too they could possibly be another MGS game. A possible route can they take is that another of the Les Enfant Terribles didn't die & you have a ready made villain right there (Liquid mentions to Snake in MGS they were originally Octuplets). It also wouldn't be beyond Kojima to retcon some part of the story to bring a villain back I mean the series is full of retcons already!

My only problem with MGR:R is that instead of sticking with a gamestory that bridges MGS2 & MGS4 together, which is the game I for one really wanted, we're potentially getting something new. I guess we'll just have to wait & see!