The only games that mash my hands up are fighting games that use all the face buttons like Tekken, 'cause I hold the pad only with my left hand and right hand I have my index and middle finger on the face buttons and the rapid repeated use over a long period of time makes my wrist and the back of my hand ache like tit. Other than that I'm pretty much fine with anything I think. Some of the stuff that kills peoples hands makes no sense to me at all, whenever I've been playing DW7 with Paul and he complains about it killing his hands I can't even comprehend how you could hold a pad in a way that would hurt your hands while playing that game, or why you'd need to.

edit: forgot, used to blister my thumbs something rotten playing 2D fighters, Street Fighter, guilty gear etc etc. It's pretty much just fighting games that kill my hands in some way or another.