I like when the characters say 'screw destiny' but it turns out they can't escape it after all. FFXIII did it, but then screwed it up in the end. FFXIII-2 did it too, and again screwed it up in the end (the very very end at least). I'm not a fatalist, but I do like when things happen as they are supposed to happen.

It would be refreshing to see a game where the villain is the one who was destined to be the hero, but said 'screw destiny' and became a bad guy. I'm sure it's been done but I can't think of any off the top of my head.