Okay, here's the simple version:
FF Origins has two difficulty settings. "Normal" has the exact same difficulty as the NES version. Items cost the same amount of Gil, and the amount of maximum spell charges per spell level is 9. "Easy" basically cuts the price of every item, and your spell capacity increases. A lot.
There are exceptions difficulty-wise: auto-targeting (which can be turned off) and the ability to use Life, Life2 and Stona in battle (which can be turned off.)
The two major things in Origins that cannot be just like the original: inventory management (the original let you carry four pieces of armour and four weapons per character; Origins puts them in with your items and you can carry every item in the game this way, which significantly reduces difficulty) and this little quicksave feature that allows you to temporarily save the game anywhere.
And here's the summary of that:
Summary
Choose Normal difficulty, switch off auto-targeting, and switch off the "Battle support" option. Aside from what you can't change it will be almost exactly like the NES version challenge-wise. Don't abuse the quicksave, and count your blessings on the new inventory system. Enjoy.
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