Oh my god I had a big post typed up and then I hit quote and lost the whole smurfing thing augh augh augh. Gist: Toby MacGuire was to nerdy to play Spider-Man, but nerdy enough to play Peter Parker. This new incarnation of Peter Parker is less nerdy and I think that's ok. Having Gwen Stacy in there helped make the origin stuff less boring, but I'd still prefer a reboot that just assumes you know who Spider-Man is and doesn't have to explain it to you in so much detail.
This movie wins for having the only Stan Lee cameo in the history of Stan Lee cameos that didn't make me want to reach into the screen and strangle him.
I thought it was pretty obvious that, on top of turning him into a giant lizard, the serum drove Connors insane. The giant rat was there to show Peter that the serum turns things into monsters. I think the Indian dude hit his head and died in the car, though I'm not sure and they really should have made it more obvious if that's the case. And the guy who killed Uncle Ben not getting caught gives Spider-Man another reason to keep fighting crime. Peter still had the police sketch pinned to his bulletin board at the end of the movie for a reason.