I have the same GPU and it is a monster. Not really top of the line, but you'll be able to run pretty much any current title on high settings, barring some bleeding edge hardware crusher like the Witcher 2 or something. You won't get much expandability with the micro-ATX motherboard, but if that's not an issue for you then I see no reason not to get is. Like Bert said I'd probably go with more RAM because why the hell not? An extra $40 for a total of 16GB isn't bad. You can always upgrade it later though if you want to save the money now and feel it becomes an issue down the road.

I should point out though that the hard drive you've selected is a laptop hard drive. Go with one of the Western Digital Caviar models instead. As long as you're going with a 3.5" drive you're getting a desktop drive. You can get enclosures for laptop drives I believe so they can be placed in a desktop, but why bother with the hassle if you can avoid it.

Everything else looks good.