Hm nope, I have tried everything I can think of but my computer obstinately refuses to work properly with NesTopia.
Not even FCEUX, Jnes, Nintendulator or Virtuanes work well enough, they always have too bright colours, ugly sounds or refuse to look good in Full Screen.
Bah, I'm getting so tired of this.

But anyway, the strange thing is that today I tested an old NesTopia emulator that I have on my mother's desktop computer from back before I moved away, and it turned out to work perfect.
No lag or anything at all, the sound worked totally fine and never fell behind and jumped back in sync over and over, like it always does on my computer.
What's even stranger is that she has a pretty old computer (Dell Dimension 5000, about ten years old I guess) and my Asus laptop is from 2008.

Maybe NesTopia simply works better on desktop computers?