My favorite thing to do is make it to The End of Time so that I may fight Spekio in his Tadpole state, and then win that Magic tab so that I may give it to Robo, starting already the bat trout insanity that is the Robo Heal master.

I usually try to knock out Genocide dome early, just because of the stat bumps to Robo.

That and Ozzies fort for Magus's Gear.

Otherwise it's no particular order for me.