Lost Odyssey has two parents who have lost a child. And it's smurfing heart-breaking.

Vivi was physically handicapped in that he was short and clumsy. Also, relative to Sabin, pretty much everyone in FFVI is physically handicapped, because Sabin is the god of bears.

I would like a main character to actually be an Imp. Not a person in Imp status, but an actual Imp. And his quest would revolve around them hunting the legendary Imp equipment. Good times.