I would say the biggest drawback is it's a little lacking in some genres, particularly Sports and JRPG's. So if you want a lot of a particular game genre, best to check if the PC carries a lot of it.

Even then, I'd say this is a relatively minor drawback, as services like GoG and Steam allows for a good thirty or so years worth of games that's at your fingertips if you know what you're doing. Also, PC is the undisputed king console for WRPG's, Strategy, Simulation, and MMO's as well. Not to mention the ability to mod certain games, which consoles are unfriendly for.

So, if you can deal with the cost, have a bit of time, and aren't viewing the PC as just another console, a PC could potentially be the most satisfying gaming investment of your life.