I would actually recommend Dragon Age: Origins. It was one of the more memorable experiences for me on my Xbox 360.
For PS3:
3D Dot Game Heroes is quite fun. It's basically an homage to the early Legend of Zeldas done in voxel form.
Ni No Kuni is entertaining.
Valkyria Chronicles is one of the best on the system.
Not sure if anybody mentioned it, but if you haven't tried out one of the Souls games, those are quite enjoyable. Demon's Souls is a good start to it.
Depending on what PS2 games you've played, the HD versions of many game series are still fun. Okami HD and Ico/Shadow of the Colossus being my favorites.
For the Wii:
I've got nothin' you haven't played. ;o