Mother 3 and Seiken Densetsu 3. I know I can emulate fan translations but every time I've tried it just doesn't feel right. I want to play them on a console or handheld!

Also some others I haven't had the chance to play since I didn't have the right system at the time of their release:

Mass Effect
Tales of Symphonia
Skies of Arcadia

At least the first two are now out on PS3 so I'm going to give them a go once I have time. The Walking Dead Season 2 and Suikoden 2 are taking up my time currently.