I might be biased or looking at this wrong because I've never seen whatever anime that top one is but it looks pretty good to me. Give her purple hair and some contacts and she's good to go

Anyways, actors I can no longer take seriously in any role other than the one I've personally type-cast them as:

Chris Pratt (once Star-Lord, forever Star-Lord)
The entire cast of Arrested Development, especially Will Arnett. He will always be Gob to me.