Depends. Is this a theoretically setting where theoretical games that should exist actually do exist? In that case I'd have to give some serious consideration to Half-Life. Again, this is assuming that HL2:E3 and HL3 and P3 actually exist (and don't ruin the franchise).
It's really hard to not pick Final Fantasy. There's just so much there. But I could probably be content with Zelda, Metroid, or TES, too.