I was gonna propose Baldur's Gate, though that is probably because I'm really into it now. It's certainly different to what you're used to, but it's still a fantastic game, so let's see how it'll measure up against your criteria (also, treating BG1 and 2 as a single entity here)

Quote Originally Posted by Pumpkin View Post
-I am looking for an RPG. It can be an action RPG or a Strategy RPG or any kind of RPG.
Definitely an RPG. A WRPG based on the AD&D second edition ruleset. It's turn-based, but the turns all play out fast, so it almost plays like real time. Sounds weird, but it works. Kinda similar to FFXII.

-A decent sized cast of characters. Not a game with like 3 characters. I'd say at least 5, although the more the better
You get 6 spots in your party. In BG1 you get to choose from around 30 characters, but aside from a quest each and a couple throw-away lines, they're not too complex. In BG2 you get much less to choose from, but they all have questlines, arcs, loads of banter with the other characters and even romances.
-Some good female characters
So I think in both games around half of the characters are female, and a lot of them are really memorable and good (especially in BG2). Heck, it's perfectly possible to have an all-female party.
-An easy enough game or at least one with a difficulty setting
It has five difficulty settings. I just found out I was playing on a lower difficulty that normal and it was too easy for me, but there is an even easier mode than that.

Optional:
-I prefer anime style art in the game, but that's not a need
Yeah, you won't get that here. I had a hard time getting used to the style, but it grew on me. The character sprites differ little from each other, and the portraits, while varied, are a mixed bag. They look like photoshopped photos in BG1, and memorable and pleasant (albeit a bit cheap looking) paintings in BG2. Luckily, the new portraits added in the Enhanced Edition look awesome. Plus, you can always import your own.
-Some humour in a game would be nice
Tons of it, in the dialogue mostly. Especially with some of the crazy evil characters. It's mostly pretty dry, and I love it
-Dating sims are always a plus
You get a pretty epic romance sidequest in BG2. It's really great.
-If the majority cast was female or even the main protagonist, that would be great
Like I said, it's perfectly possible to have an all-female party, and your main character is an avatar you create, so nothing's stopping you from making it a girl that you decide the personality of. The Forgotten Realms setting is pretty equalist, so no one ever belittles your character for being a female and all characters have equal opportunities when it comes to stats and all.