Shepherd and Garrus. No matter your gender. No matter your romantic interests. That man will follow you into anything. Murder anyone who so much as looks at you funny. And quip great one liners even after taking a rocket to the face. I have a huge man crush on him. He's the friend to beat all friends

The protagonist and Alistair have a similar relationship in Dragon Age. Just not as bad ass and intense. But Garrus had 3 games to build that up